Chemo-Differentiating ABB′ Multicomponent Reactions: Privileged Building Blocks

Amines as key building blocks in Pd-assisted multicomponent processes

In the last few years, palladium-mediated three-component synthesis has emerged as an important synthetic methodology to gain access to nitrogen-containing structures. The latest developments in this area are discussed in this review.

Multicomponent Reactions

Multicomponent reactions

Chemistry as a central science is facing a steadily increasing demand for new chemical entities (NCE). Innovative solutions, in all kinds of disciplines that depend on chemistry, require new molecules with specific properties, and their societal consequences are fundamental and pioneering. However, NCE not only demand a realistic structural space but also their feasibility poses challenges to s...

Vinyl sulfone building blocks in covalently reversible reactions with thiols

In the present study we use quantum-chemical calculations to investigate how the reactivity of vinyl sulfone-based compounds can be modified from an irreversible to a reversible reaction with thiols. Based on the predictions from theory, an array of nine different vinyl sulfones with systematically varying substitution pattern was synthesized and their crystal structures were determined. Subseq...

Carbohydrates as building blocks of privileged ligands for multiphasic asymmetric catalysis.

To combine the high chemical performance of asymmetric catalysis with the increasing need for sustainability, a strategy is presented that involves the straightforward preparation of "Trost"-like ligands suitable for application in multiphasic homogeneous catalysis. Ligands with coordinating functions (phosphinoamide-phoshinoester groups) as well as phase tags introduced on a D-glucose scaffold...